About This PheWeb


Results displayed in this PheWeb include genome-wide associations for EHR-derived ICD-9 billing codes from participants of the Michigan Genomics Initiative. Phenotypes were classified into 1,780 broad PheWAS codes with counts ranging from 20 – 19,244 cases and 11,440 – 42,094 controls. All individuals were genotyped on the Illumina HumanCoreExome Array and imputed using the Haplotype Reference Consortium panel, resulting in >20 million variants. Analyses on binary outcomes were conducted using SAIGE (a generalized mixed model association test that uses the saddlepoint approximation to account for case-control imbalance), adjusting for genetic relatedness, age, sex, chip version and the first 4 principal components. All genomic positions are on GRCh37.


This site was built with PheWeb. If you have questions about this dataset, email anitapan@umich.edu or mgi.statgen@umich.edu. If you have questions about this website, email pjvh@umich.edu.