Results displayed in this PheWeb include genome-wide associations for EHR-derived ICD billing codes from the White British participants of the UK Biobank. Phenotypes were classified into 1,403 broad PheWAS codes with counts ranging from 51 – 77,977 cases and 330,366 – 408,908 controls. All individuals were imputed using the Haplotype Reference Consortium panel, resulting in >20 million variants. Analyses on binary outcomes were conducted using SAIGE (a generalized mixed model association test that uses the saddlepoint approximation to account for case-control imbalance), adjusting for genetic relatedness, sex, birth year and the first 4 principal components. All genomic positions are on GRCh37.
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